Ann Russell, a mum-of-two and grandmother to three, is helping scientists at the Cancer Research UK Cambridge Institute and a team of international researchers on a £20 million Grand Challenge project looking at new ways to tackle cancers linked to chronic inflammation. The project was selected for the funding by an international panel of experts considering a shortlist of 10 exceptional, multi-disciplinary collaborations from universities, institutes and industry across the globe. Cancer Research UKs Grand Challenge was established to help scientists attack some of the hardest, unanswered questions in cancer research. Ms Russell, 74, is a cancer survivor herself having been treated for both bowel and bladder cancer in the past decade. She volunteers as a Cancer Research UK patient advocate to give something back. Patient advocates advise on how to improve patient involvement and engagement in research and on how clinical trials can benefit and work best for patients. The former charity HR worker has already flown over to San Francisco to help design the research proposal. She will continue to work with the research team to give a patients perspective as the project develops. Ann said: The Grand Challenge project is very exciting and I feel proud to be part of it. When I was diagnosed with cancer, it was a real eye-opener to me to realise the many different people involved in the treatment from the researchers working in the labs, to the teams working in the hospital with patients. I am very aware that its because of them, and all of the people who gave their time to support research in the past, that I am still here. Thats one of the reasons I wanted to get involved in research. I wanted to help people diagnosed in the future. The research groups are based in three continents. At the Cancer Research UK Cambridge Institute they are set to receive more than £1.4 million over the next five years as part of the global project. They will work with scientists in London, the USA, Canada and Israel who beat stiff international competition to secure the funding. The Cambridge scientists will be using their expertise to help unravel how chronic inflammation is linked to cancer. Inflammation is part of the bodys immune response. Chemicals released by white blood cells help protect the body from damaged cells, foreign substances or infections. Chronic inflammation can be caused by several factors such as viral and bacterial infections (including colitis), being overweight or lack of exercise, which can lead to diseases such as cancer. It is suggested that up to one in four cancers globally are linked to inflammation. Dr Doug Winton, group leader at the Cancer Research UK Cambridge Institute, said: We are very excited to be collaborating on this pioneering project. This project unites different kinds of researchers - biologists, physicists and engineers who can challenge the way we currently treat cancer caused by inflammation. Recent work shows that the cells surrounding cancers can control whether or not the cancer grows or disappears. The aim is to determine whether its possible to treat the inflamed cells and non-cancerous stromal cells (those cells immediately surrounding cancer cells) rather than treating the cancer cells directly. This could help scientists devise exciting new approaches to treatment from repurposing everyday anti-inflammatory drugs, to designing cells that target cancer-promoting tissues. Dr Winton continued: This research has the potential to increase our ability to prevent this type of cancer in high-risk patients. The scale of the project is huge and would not be possible without the Grand Challenge funding. For more information, visit: www.cruk.org.uk\/grandchallenge.