The A14 has been closed in both directions between Huntingdon and Alconbury after what police described as “multiple collisions”.
Officers are advising people to find alternative routes as emergency services work to clear the scene.
A collision between a lorry and a van at about 3.45pm caused a blockage on the A14 Alconbury spur between the A1 junction 14 and junction 23, the Spittals interchange.
Meanwhile, an earlier accident involving two cars and a lorry forced highways officials to close one lane of the A14 at J27, near Fenstanton
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