The Highways Agency has announced nearly six weeks of roadworks on the A14 for resurfacing between St Ives and Girton.
There will be overnight closures on the 12.6-mile length of dual carriageway, starting on Thursday, October 23.
The work, which includes resurfacing and patching, renewing road markings and road studs, will cost £3million.
It will start with the westbound side, which will be worked on in three phases and is due to be finished, depending on the weather, by December 2. Once complete, work on the eastbound carriageway is also due to take place.
Phase one will include the A14 near the westbound St Ives turn off, with overnight closures from 8pm and 6am from Thursday, October 23 to Friday, November 7.
The second phase, involving the westbound A14 between Girton and Bar Hill, will take place at the same time as the first.
Phase three will take place on the A14 westbound carriageway between St Ives and Bar Hill from Monday, November 10 to Tuesday, December 2.
Traffic will be diverted along the A428 and the A1.
The HA says access for residents will be retained at all times, with residents who require access escorted past the roadworks by members of the site team.
It also says the timetable could change, depending on the weather.
Highways Agency project manager, Dave Elwyn said: "This is a £3million scheme which is taking place to prolong the life of the carriageway.
"The work has been designed to improve the surface of the road and improve safety for road users, while minimising the need for future maintenance works in these locations.
"We ask that drivers take care travelling through the roadworks and along the diversion routes, follow the traffic signs and any instructions of site staff.
"We have planned the work to be carried out in phases and overnight, when traffic flows are at their lowest, to minimise disruption."