# SEROXAT was originally manufactured by GlaxoSmith-Kline, although it is now out of patent so that other companies can make it. In May, GlaxoSmithKline wrote to doctors warning them to carefully monitor all patients on Seroxat, especially young adults, a
# SEROXAT was originally manufactured by GlaxoSmith-Kline, although it is now out of patent so that other companies can make it. In May, GlaxoSmithKline wrote to doctors warning them to carefully monitor all patients on Seroxat, especially young adults, after trials showed a "higher frequency of suicidal behaviour" among people of all ages being treated with the drug, compared to those taking a placebo.
A spokesman for GlaxoSmithKline said: "Seroxat (paroxetine) has only ever been licensed for use for over 18s. With a clinical trial programme involving some 24,000 subjects and its use in tens of millions of patients around the globe, paroxetine has become one of the world's most closely studied medicines since its launch in 1991.
"As with all medicines, SSRI anti-depressants can cause side effects in some people. Information is provided to doctors and patients and is updated as we learn more from clinical trials and monitoring of patients world-wide."
GSK denies the allegation it withheld information on Seroxat being unsuitable for under 18s.
The spokesman said: "We reject any suggestion that we attempted to hide results or mislead regulators or the medical community over paediatric clinical trial data for paroxetine. GlaxoSmithKline is co-operating fully with the MHRA's ongoing investigation."
# ROACCUTANE for the treatment of acne and LARIUM the anti-malarial drug are both made by Hoffman-La Roche.
Roche admits that mood changes caused by Roaccutane can include "depression or symptoms of mental disorders and in rare cases suicide and attempts of suicide".
It says: "Over the past 20 years, Roaccutane has been used to treat over 13 million people suffering from severe acne. Roaccutane is normally prescribed by a specialist, usually a dermatologist, and - before a patient begins treatment - the dermatologist will explain these risks and make sure the patient understands them.
For many patients with severe acne, Roaccutane offers a treatment of last resort and the only hope of controlling and treating their condition.
No research or study has ever established that Roaccutane causes patients to commit suicide or attempt it.
On Lariam, Roche says: "Although no link between Lariam and suicide has ever been established, the drug does carry a warning that there have been rare reports of suicide.
"However, this is a precaution and Lariam remains one of the drugs of choice for the prevention and treatment of malaria by leading public health authorities, including the World Health Organisation and the US Centers for Disease Control."
# PROZAC and DULOXETINE are made by Eli Lilly. Asked to comment on the statement that the drugs could cause a risk of suicide in some people, a spokesman said: "It's difficult to give a brief response to such a complex issue." He added that several other companies now made Prozac, which is out of patent.
# EFEXOR (or venlafaxine) is made by Wyeth, who said in response to the suggestion that the drug could be linked to a higher risk of suicide: "While we are unable to comment on individual patients, depression is a serious disease that requires the careful consideration of a variety of therapeutic and non-therapeutic treatment options.
"Since the development of newer treatment options, like venlafaxine, the overall incidence of suicide has declined. In the past 10 years, more than 1.25 million patients have been treated with venlafaxine in the UK."
A spokesman added that both weight gain or loss are listed in the summary of product characteristics.
# DIANETTE is made by Schering. A spokesman said: "Dianette should only be prescribed for the treatment of severe acne, which has not improved after the long-term use of antibiotics, or for excessive hair growth on the face and body. It is also an effective contraceptive, but it should not be used solely for contraception. Severe depression is listed in the patient information leaflet as a reason for stopping Dianette immediately." Depressive moods are also listed as possible side effect.
# CIPRAMIL (citalopram) and CIPRALEX (escitalopram) are made by Lundbeck. A spokesman said: "There is no indication that citalopram or escitalopram lead to increased suicide risks. On the contrary, there is evidence that (the drug) reduces suicidal thoughts.
"Weight increase or decrease has been reported as a less frequent side effect of Cipramil, occurred in 1-5 per cent of patients in clinical trials."
# LUSTRAL is made by Pfzer. A spokesman said: "Sertraline (Lustral) is approved for the short and long-term treatment of multiple mood and anxiety disorders. In a review of 156 controlled studies, the risk of suicide-related events was similar in over 11,000 patients taking placebo or sertraline, regardless of baseline suicide risk.
"No causal association was seen between sertraline treatment and suicidal thinking or behaviour."
# RISPERDAL (resperidone) is made by Janssen, who confirm that it can cause some people to put on weight.